2019 ALDH2STAR, Program

Program

Sep. 27^th ~ 28^th, 2019

Performing Center, First Teaching Building, Kaohsiung Medical University, Taiwan

Day 1
Day 2

Day 1	Friday, September 27^th , 2019
08:50 09:20	Registration

Opening, Welcome and Announcement
09:20 09:30	Wen-Chun Hung, Ph.D., Vice President Kaohsiung Medical University, Taiwan Che-Hong Chen, Ph.D., CEO International ALDH2 STAR Research Consortium, Stanford University, U.S.A.
09:30 09:40	Opening Remark Guest of Honor: Chien-Jen Chen, Ph.D. (TBD) Vice President of the Republic of China & Academia Sinica, Taiwan
09:40 09:45	Group Photo

Session 1: ALDH2 and Precision Medicine
Moderator: Ming-Tsang Wu, M.D., Sc.D., MOH / Kaohsiung Medical University, Taiwan
09:45 10:10	Novel and Prevalent Non-East Asian ALDH2 Deficit Variants; Implications for Global Susceptibility to Aldehyde Toxicity Daria Mochly-Rosen, Ph.D. Dept. Chemical and Systems Biology, Stanford University, U.S.A.
10:10 10:35	Reducing Toxic Aldehydes for Treatment of Obesity, Insulin Resistance and Fatty Liver Meng-Lun Hsieh, M.A. Dept. Internal Medicine, National Taiwan University, Taiwan
10:35 10:50	Coffee Break
10:50 11:15	Associations of Chronic Ethanol Exposure and Cardiac Electromechanical Disturbances in ALDH2 Deficiency: from Bench to Clinical Findings Chung-Lieh Hung, M.D., Ph.D. Dept. Cardiology, Mackay Memorial Hospital, Mackay Medical College, Taiwan
11:15 11:40	Measuring Aldehyde Levels in the Breath for Application during Surgery Eric Gross, M.D., Ph.D. Dept. Anesthesiology, Perioperative and Pain Medicine, Stanford University, U.S.A.
11:40 12:05	Aldehyde Dehydrogenase Induction in Arsenic Carcinogenesis Chee-Yin Chai, M.D., Ph.D. Dept. Pathology, Kaohsiung Medical University Hospital, Taiwan
12:05 12:30	ω-6 Oil-derived 'Hydroxynonenal' Causes Diverse Cell Death for Lifestyle Diseases Tetsumori Yamashima, M.D., Ph.D. Dept. Psychiatry and Behavioral Science, Graduate School of Medicine, Kanazawa University, Japan
12:30 13:30	Lunch

Session 2: ALDH2 and Cancer
Moderator: Shyng-Shiou Yuan, Ph.D. / Kaohsiung Medical University, Taiwan
13:30 13:55	Carcinogenetic Impact of ADH1B and ALDH2 Genes on Esophageal Squamous Cell Carcinoma Risk among Alcohol Drinkers Ming-Tsang Wu, M.D., Sc.D., MOH Research Center for Environmental Medicine, Kaohsiung Medical University, Taiwan
13:55 14:20	ALDH2 and Alcohol Metabolism in Esophageal Tumor Initiating Cells Hiroshi Nakagawa, M.D., Ph.D. Columbia University Medical Center, New York, USA
14:20 14:45	The Association of Smoking, Alcoholic Consumption, and Betel Quid Chewing in Oral Cavity Cancer: A Prospective Cohort Study Shih-An Liu, M.D., Ph.D. Dept. of Otolaryngology Head & Neck Surgery, Taichung Veterans General, Taiwan
14:45 15:10	ALDH2 Deficiency Promotes Pericellular Fibronectin-Mediated Cancer Metastasis Hung-Chi Cheng, Ph.D. Dept. Biochemistry and Molecular Biology, National Cheng-Kung University, Taiwan
15:10 15:30	Coffee Break
15:30 17:00	Poster Session & Networking

Day 2	Saturday, September 28^th , 2019
08:30 09:10	Registration & Networking

Session 3: ALDH2 and Public Health
Moderator: Chih-Hsing Hung, M.D., Ph.D. / Kaohsiung Municipal Siaogang Hospital, Taiwan
09:10 09:30	ALDH2 Deficiency-Public Health Considerations for Taiwan Che-Hong Chen, Ph.D. Dept. Chemical and Systems Biology, Stanford University, U.S.A.
09:30 09:50	Alcohol, ALDH2 and Stanford WELL for Life Study Ann Hsing, Ph.D. Stanford Prevention Research Institute, Stanford University, U.S.A.
09:50 10:10	Policy Options of Regulating Alcoholic Consumptions for Tackling ALDH2 Problems in Taiwan Kuei-Jung Ni, Ph.D. in Law Wan-Tsui Chiang, S.J.D. Institute of Technology Law, School of Law, National Chiao Tung University, Hsinchu, Taiwan
10:10 10:30	Group Photo / Coffee Break
10:30 12:00	Forum on Alcohol Intolerance & Alcohol Public Health Policy Audience & Panel Discussion Chair: Chang-Chuan Chan, Ph.D. College of Public Health, National Taiwan University, Taiwan
12:00 13:00	Lunch / Networking

Session 4: ALDH2 and Therapeutic Opportunities
Moderator: Wen-Jeng Wu, M.D., Ph.D. / Kaohsiung Medical University, Taiwan
13:00 13:25	4HNE-induced Dicer Inactivation: A New Opportunity for Aldas Julio C. B. Ferreira, Ph.D. Institute of Biomedical Sciences, University of Sao Paulo, Brazil
13:25 13:50	Current Status of Alcoholism and Disease Burden in Mongolia Unenbat Gurbadam, M.D. Dept. Hepato-Pancreato Biliary Surgery, National Cancer Center, Mongolia
13:50 14:15	Autoantibody Against Aldehyde Dehydrogenase 2 could be a Biomarker to Monitor Progression of Graves' Orbitopath Kai-Chun Cheng, Ph.D. Dept. Ophthalmology, Kaohsiung Municipal Siaogang Hospital, Taiwan
14:15 14:40	Developing Mitochondrial Aldehyde Dehydrogenase (ALDH2) Activators for Unmet Medical Needs Wenjin Yang, Ph.D. Chief Scientific Officer, Foresee Pharmaceuticals, Taiwan
14:40 14:55	Coffee Break
14:55 15:20	Protective effects of Alda-1 on Alcohol-derived DNA Damage in the Esophagus of Human ALDH2*2 (Glu504Lys) Knock-in Mice Kenshiro Hirohashi, M.D. Dept. Therapeutic Oncology, Kyoto University Graduate School of Medicine, Japan
15:20 15:45	Aldehyde Exposure in Fanconi Anemia Patients, Investigating its Role in the Etiology of Head and Neck Cancer Silvia Balbo, Ph.D. Division of Environmental Health Science and Masonic Cancer Center, University of Minnesota, U.S.A.
15:45 16:10	Protection of Hematopoietic Stem Cells by Activating Aldehyde Metabolism to Treat Fanconi Anemia Jennifer Tsai, M.D. Pediatric Hematology/Oncology Division, Children’s Hospital, Stanford University U.S.A.
16:10 16:30	Discussion & 2020 ALDH2 STAR Symposium
16:45 17:00	Awards Ceremony & Closing Remarks

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Kaohsiung Medical University & Stanford University

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